O-Glycan biosynthesis
| PAG Title | O-Glycan biosynthesis |
| PAG ID | WIG000580 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 3,341 |
| Information Content | Rich |
| Other IDs | M6929 |
| Base PAG ID | WIG000580 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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